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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	13426-16-9
Molecular formula	C12H10N2O2
IUPAC name	6-anilinopyridine-3-carboxylic acid
Molecular weight	214.224
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.3
Synonyms	MCULE-8252964641 2-Anilinopyridine-5-carboxylic acid 6-anilinopyridine-3-carboxylic Acid CTK0H1830 FT-0746969 OR01774 6-(phenyl-amino)-pyridine-3-carboxylic acid AC1MCKIR KB-82339 ZINC6733575 6-(phenylamino)nicotinic acid MolPort-001-756-575 3-Pyridinecarboxylic acid, 6-(phenylamino)- 6-phenylamino-nicotinic acid DB-063019 GL-0339 PS-3089 6-(phenylamino)-3-Pyridine carboxylic acid AJ-56781 KS-00001OVN ZX-AT000856 6-(phenylamino)pyridine-3-carboxylic acid CHEMBL237738 OMGPNSFUSJHLFT-UHFFFAOYSA-N 3-Pyridinecarboxylicacid, 6-(phenylamino)- 6-phenylamino-nicotinic acid, AldrichCPR DTXSID70378107 K-4230 SCHEMBL71308 6-(Phenylamino)-3-pyridinecarboxylic acid AKOS000215627 [ Show all ]
Inchi Key	OMGPNSFUSJHLFT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H10N2O2/c15-12(16)9-6-7-11(13-8-9)14-10-4-2-1-3-5-10/h1-8H,(H,13,14)(H,15,16)
PubChem CID	2771812
ChEMBL	CHEMBL237738
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3235.94 nM	PMID17931863	ChEMBL

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