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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Mu-type opioid receptor
Species	Mus musculus (Mouse)
Gene	Oprm1
Synonym	opioid receptor, mu 1 opioid receptor OP3 Mu receptor MOR-1 MOPr MOP M-OR-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P42866
Protein Data Bank	4dkl, 5c1m, 6dde, 6ddf
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4dkl.
BioLiP	BL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2858
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL298314
Molecular formula	C26H27NO5
IUPAC name	(4aS)-4a,9-dihydroxy-4'-methoxy-3-methylspiro[1,2,4,5,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-6,2'-1,3-dihydroindene]-7-one
Molecular weight	433.504
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.6
Synonyms	7-(4''-Methoxy-2''-spiroindanyl)oxymorphone BDBM50058149
Inchi Key	BIEACPWHNAUZTR-YASAKQTDSA-N
Inchi ID	InChI=1S/C26H27NO5/c1-27-9-8-25-20-14-6-7-17(28)21(20)32-23(25)22(29)24(13-26(25,30)19(27)10-14)11-15-4-3-5-18(31-2)16(15)12-24/h3-7,19,23,28,30H,8-13H2,1-2H3/t19?,23?,24?,25?,26-/m1/s1
PubChem CID	44293268
ChEMBL	CHEMBL298314
IUPHAR	N/A
BindingDB	50058149
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	9.2 nM	PMID9171881	BindingDB
Ki	9.24 nM	PMID9171881	ChEMBL

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