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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 1
Species	Rattus norvegicus (Rat)
Gene	P2ry1
Synonym	ATP receptor purinergic receptor P2Y Purinergic receptor platelet ADP receptor P2Y1 receptor P2Y1 P2Y purinoceptor 1 P2Y ATP receptor 1 P2 purinoceptor subtype Y1 Purinergic receptor P2Y1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	373
Amino acid sequence	MTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
UniProt	P49651
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2497
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Diadenosine Pentaphosphate
Molecular formula	C20H29N10O22P5
IUPAC name	bis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight	916.369
Hydrogen bond acceptor	30
Hydrogen bond donor	11
XlogP	-9.4
Synonyms	P1,P5-Bis(5'-adenosyl) pentaphosphate AC1L98W4 ApppppA CHEMBL437508 SCHEMBL2934890 128113-55-3 adenosine(5')pentaphospho(5')adenosine bis(adenosine)-5'-pentaphosphate P(1),P(5)-bis(5'-adenosyl) pentaphosphate 41708-91-2 Ap5A CHEBI:28898 P1,P5-Bis(5'-adenosyl)pentaphosphate Adenosine 5'-(hexahydrogen pentaphosphate), 5'.5'-ester with adenosine BDBM50435017 DB01717 EINECS 255-507-1 ZINC96085195 199995-62-5 Adenosine-(5')-pentaphospho-(5')-adenosine bis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate P(1),P(5)-Di(adenosine-5'-)pentaphosphate Ap5ACN P1,P5-Bis-(5'-adenosyl)pentaphosphate 117137-56-1 adenosine 5'-(hexahydrogen pentaphosphate), P""?5'-ester with adenosine Bis(5'-adenosyl) pentaphosphate di(adenosine-5')pentaphosphate LS-15143 2bzz AP5 C04058 [ Show all ]
Inchi Key	OIMACDRJUANHTJ-XPWFQUROSA-N
Inchi ID	InChI=1S/C20H29N10O22P5/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)20(48-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
PubChem CID	440210
ChEMBL	CHEMBL437508
IUPHAR	N/A
BindingDB	50435017
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5000.0 nM	PMID16539385	ChEMBL

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