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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 182
Species	Homo sapiens (Human)
Gene	GPR182
Synonym	NOW L1-R GPR182 Gpcr22 Gpcr17 adrenomedullin receptor ADMR [ Show all ]
Disease	N/A
Length	404
Amino acid sequence	MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProt	O15218
Protein Data Bank	N/A
GPCR-HGmod model	O15218
3D structure model	This predicted structure model is from GPCR-EXP O15218.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4356
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	NSC697162
Molecular formula	C34H38N8O4
IUPAC name	2-[[4-amino-5-[8-[4-amino-5-[(1-hydroxynaphthalen-2-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol
Molecular weight	622.73
Hydrogen bond acceptor	10
Hydrogen bond donor	4
XlogP	6.4
Synonyms	2-[[4-amino-5-[8-[4-amino-5-[(1-hydroxynaphthalen-2-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol CHEMBL363587 2,2'-{octane-1,8-diylbis[(4-amino-4h-1,2,4-triazole-5,3-diyl)methanediyloxy]}dinaphthalen-1-ol NSC-697162 AC1L97G4 CTK8D3458 2-[[4-amino-5-[8-[4-amino-5-[(1-hydroxy-2-naphthyl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol 1-Naphthalenol, 2,2'-[1,8-octanediylbis[(4-amino-4H-1,2,4-triazole-5,3-diyl)methyleneoxy]]bis- NCI60_034631 [ Show all ]
Inchi Key	OIDAYCSNXVJXMP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H38N8O4/c35-41-29(37-39-31(41)21-45-27-19-17-23-11-7-9-13-25(23)33(27)43)15-5-3-1-2-4-6-16-30-38-40-32(42(30)36)22-46-28-20-18-24-12-8-10-14-26(24)34(28)44/h7-14,17-20,43-44H,1-6,15-16,21-22,35-36H2
PubChem CID	394044
ChEMBL	CHEMBL363587
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Affinity	42.0 %	PMID15943480	ChEMBL

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