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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL82833
Molecular formula	C15H21ClN2O2
IUPAC name	1-(4-amino-5-chloro-2-methoxyphenyl)-3-piperidin-4-ylpropan-1-one
Molecular weight	296.795
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.1
Synonyms	1-(4-amino-5-chloro-2-methoxyphenyl)-3-(piperidin-4-yl)propan-1-one BHUVUNZKZDLBRF-UHFFFAOYSA-N SCHEMBL7350324 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(piperidin-4-yl)-propan-1-one BDBM50213020
Inchi Key	BHUVUNZKZDLBRF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H21ClN2O2/c1-20-15-9-13(17)12(16)8-11(15)14(19)3-2-10-4-6-18-7-5-10/h8-10,18H,2-7,17H2,1H3
PubChem CID	9882676
ChEMBL	CHEMBL82833
IUPHAR	N/A
BindingDB	50213020
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	125.89 nM	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL
EC50	126.0 nM	N/A	BindingDB
Intrinsic activity	0.52 -	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL

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