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GPCR

NameD(3) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD3
Synonymdopaminergic receptor D3
D3R
D3 receptor
dopamine D3 receptor
DiseaseUnspecified
Emesis; Gastric motility disorder
Female sexual dysfunction
Male sexual disorders
Psychotic disorders
[ Show all ]
Length400
Amino acid sequenceMASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProtP35462
Protein Data Bank3pbl
GPCR-HGmod modelP35462
3D structure modelThis structure is from PDB ID 3pbl.
BioLiPBL0191566, BL0191567
Therapeutic Target DatabaseT02551
ChEMBLCHEMBL234
IUPHAR216
DrugBankBE0000581

Ligand

NameCHEMBL389559
Molecular formulaC20H25NO
IUPAC name12-methyl-12-azatricyclo[14.4.0.03,8]icosa-1(20),3(8),4,6,16,18-hexaen-6-ol
Molecular weight295.426
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.5
SynonymsZINC28711632
8-methyl-5,6,7,8,9,10,11,16-octahydrodibenzo[e,h]azacyclododecene-3-ol
BDBM50219147
Inchi KeyBHUNVFVEHNURLZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H25NO/c1-21-12-4-8-16-6-2-3-7-17(16)14-19-10-11-20(22)15-18(19)9-5-13-21/h2-3,6-7,10-11,15,22H,4-5,8-9,12-14H2,1H3
PubChem CID17755868
ChEMBLCHEMBL389559
IUPHARN/A
BindingDB50219147
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3964.0 nMPMID17676831BindingDB,ChEMBL

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