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GPCR

NameP2Y purinoceptor 6
SpeciesHomo sapiens (Human)
GeneP2RY6
Synonympyrimidinergic receptor P2Y
P2Y6 receptor
P2Y6
P2Y purinoceptor 6
P2Y ATP receptor 6
[ Show all ]
DiseaseN/A
Length328
Amino acid sequenceMEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
UniProtQ15077
Protein Data BankN/A
GPCR-HGmod modelQ15077
3D structure modelThis predicted structure model is from GPCR-EXP Q15077.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4714
IUPHAR326
DrugBankN/A

Ligand

NameCHEMBL608851
Molecular formulaC16H31N3O11P2S
IUPAC nameN,N-diethylethanamine;[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] methyl hydrogen phosphate
Molecular weight535.442
Hydrogen bond acceptor13
Hydrogen bond donor5
XlogPNone
SynonymsN/A
Inchi KeyBHTKNPGMRZRQDW-BKZSBQMKSA-N
Inchi IDInChI=1S/C10H16N2O11P2S.C6H15N/c1-20-24(16,17)23-25(18,19)21-4-5-7(13)8(14)9(22-5)12-3-2-6(26)11-10(12)15;1-4-7(5-2)6-3/h2-3,5,7-9,13-14H,4H2,1H3,(H,16,17)(H,18,19)(H,11,15,26);4-6H2,1-3H3/t5-,7-,8-,9-;/m1./s1
PubChem CID44627588
ChEMBLCHEMBL608851
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC5010400.0 nMPMID19902968ChEMBL

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