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Name | 5-hydroxytryptamine receptor 4 |
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Species | Homo sapiens (Human) |
Gene | HTR4 |
Synonym | 5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4 |
Disease | N/A |
Length | 388 |
Amino acid sequence | MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT |
UniProt | Q13639 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q13639 |
3D structure model | This predicted structure model is from GPCR-EXP Q13639. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1875 |
IUPHAR | 9 |
DrugBank | BE0000084 |
Name | CHEMBL2440453 |
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Molecular formula | C22H31N3O3 |
IUPAC name | N-[[1-(3-hydroxybutyl)piperidin-4-yl]methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide |
Molecular weight | 385.508 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.5 |
Synonyms | SCHEMBL6909544 BDBM50442803 L019604 |
Inchi Key | BHQIBLIRLOZADN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H31N3O3/c1-16(26)7-11-24-12-8-17(9-13-24)15-23-21(27)20-18-5-2-3-6-19(18)25-10-4-14-28-22(20)25/h2-3,5-6,16-17,26H,4,7-15H2,1H3,(H,23,27) |
PubChem CID | 9886435 |
ChEMBL | CHEMBL2440453 |
IUPHAR | N/A |
BindingDB | 50442803 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.7943 nM | PMID24113240 | ChEMBL |
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