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GPCR

Name5-hydroxytryptamine receptor 5A
SpeciesMus musculus (Mouse)
GeneHtr5a
SynonymMR22
Htr5
5HT5-
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
5-HT5alpha
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProtP30966
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3597
IUPHAR10
DrugBankN/A

Ligand

NameCHEMBL125361
Molecular formulaC24H30N2
IUPAC name5-methyl-2-(6-phenylhexyl)-3,4-dihydro-1H-pyrido[4,3-b]indole
Molecular weight346.518
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP5.7
SynonymsBDBM50132093
5-Methyl-2-(6-phenyl-hexyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Inchi KeyOEFBIQFHDCQKBI-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H30N2/c1-25-23-15-9-8-14-21(23)22-19-26(18-16-24(22)25)17-10-3-2-5-11-20-12-6-4-7-13-20/h4,6-9,12-15H,2-3,5,10-11,16-19H2,1H3
PubChem CID44351101
ChEMBLCHEMBL125361
IUPHARN/A
BindingDB50132093
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki435.0 nMPMID12930153BindingDB,ChEMBL

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