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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL444343
Molecular formula	C26H28N2O5
IUPAC name	N-[(E)-[3,5-dimethoxy-4-[(4-propan-2-ylphenyl)methoxy]phenyl]methylideneamino]-4-hydroxybenzamide
Molecular weight	448.519
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50110071 N''-(4-(4-isopropylbenzyloxy)-3,5-dimethoxybenzylidene)-4-hydroxybenzohydrazide 4-Hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-3,5-dimethoxy-phenyl]-meth-(E)-ylidene]-hydrazide
Inchi Key	BGYAXBYYDSKEBD-JFLMPSFJSA-N
Inchi ID	InChI=1S/C26H28N2O5/c1-17(2)20-7-5-18(6-8-20)16-33-25-23(31-3)13-19(14-24(25)32-4)15-27-28-26(30)21-9-11-22(29)12-10-21/h5-15,17,29H,16H2,1-4H3,(H,28,30)/b27-15+
PubChem CID	44373502
ChEMBL	CHEMBL444343
IUPHAR	N/A
BindingDB	50110071
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	690.0 nM	PMID11844695	ChEMBL
IC50	690.0 nM	PMID11844695	BindingDB

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