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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 182
Species	Homo sapiens (Human)
Gene	GPR182
Synonym	NOW L1-R GPR182 Gpcr22 Gpcr17 adrenomedullin receptor ADMR [ Show all ]
Disease	N/A
Length	404
Amino acid sequence	MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProt	O15218
Protein Data Bank	N/A
GPCR-HGmod model	O15218
3D structure model	This predicted structure model is from GPCR-EXP O15218.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4356
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	NSC697163
Molecular formula	C34H38N8O4
IUPAC name	1-[[4-amino-5-[8-[4-amino-5-[(2-hydroxynaphthalen-1-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-2-ol
Molecular weight	622.73
Hydrogen bond acceptor	10
Hydrogen bond donor	4
XlogP	6.4
Synonyms	2-naphthalenol, 1,1'-[1,8-octanediylbis[(4-amino-4h-1,2,4-triazole-5,3-diyl)methyleneoxy]]bis- CHEMBL195587 1-[[4-amino-5-[8-[4-amino-5-[(2-hydroxy-1-naphthyl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-2-ol NSC-697163 AC1L97G7 CTK8D3464 1-[[4-amino-5-[8-[4-amino-5-[(2-hydroxynaphthalen-1-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-2-ol 1-((4-Amino-5-(8-(4-amino-5-(((2-hydroxy-1-naphthyl)oxy)methyl)-4H-1,2,4-triazol-3-yl)octyl)-4H-1,2,4-triazol-3-yl)methoxy)-2-naphthol NCI60_034632 [ Show all ]
Inchi Key	NUXQTLBRCMZPEU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H38N8O4/c35-41-29(37-39-31(41)21-45-33-25-13-9-7-11-23(25)17-19-27(33)43)15-5-3-1-2-4-6-16-30-38-40-32(42(30)36)22-46-34-26-14-10-8-12-24(26)18-20-28(34)44/h7-14,17-20,43-44H,1-6,15-16,21-22,35-36H2
PubChem CID	394045
ChEMBL	CHEMBL195587
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Affinity	46.0 %	PMID15943480	ChEMBL

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