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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	CHEMBL605512
Molecular formula	C17H28N4O17P2
IUPAC name	[(2R,3R,4S,5S,6S)-6-(2-aminoethylcarbamoyl)-3,4,5-trihydroxyoxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight	622.37
Hydrogen bond acceptor	18
Hydrogen bond donor	10
XlogP	-9.9
Synonyms	Diphosphoric acid 1''''-alpha-D-[1''''](glucuronic acid-N-(2-amino-ethyl amide))pyranosyl ester 2-(uridin-5''-yl)ester MRS-2820 BDBM50304036
Inchi Key	NTUHCGAEPLZOPI-PKIMDUCDSA-N
Inchi ID	InChI=1S/C17H28N4O17P2/c18-2-3-19-14(28)13-10(25)9(24)12(27)16(36-13)37-40(32,33)38-39(30,31)34-5-6-8(23)11(26)15(35-6)21-4-1-7(22)20-17(21)29/h1,4,6,8-13,15-16,23-27H,2-3,5,18H2,(H,19,28)(H,30,31)(H,32,33)(H,20,22,29)/t6-,8-,9+,10+,11-,12-,13+,15-,16-/m1/s1
PubChem CID	46226445
ChEMBL	CHEMBL605512
IUPHAR	N/A
BindingDB	50304036
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2590.0 nM	PMID19502066	BindingDB,ChEMBL

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