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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 5B
Species	Rattus norvegicus (Rat)
Gene	Htr5b
Synonym	MR22 HTR5B GPR134 G protein-coupled receptor 134 5-HT-5B 5Ht5b 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene 5-ht5b receptor 5-HT5B Serotonin receptor 5B [ Show all ]
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MEVSNLSGATPGIAFPPGPESCSDSPSSGRSMGSTPGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPQESETVFTARCRATVAFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR
UniProt	P35365
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2619
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular formula	C11H16INO2
IUPAC name	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular weight	321.158
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.5
Synonyms	SCHEMBL293580 2,5-dimethoxy-4-iodoamphetamine hydrochloride 82830-53-3 BGMZUEKZENQUJY-UHFFFAOYSA- D07XTU GTPL147 NCGC00015302-04 [125I]4-iodo-2,5-dimethoxyphenylisopropylamine 1-(4-Iodo-2,5-dimethoxyphenyl)-2-aminopropane AC1Q1QZQ CCG-204558 DOI,(+) L000011 PDSP1_001383 ( -)-DOI 2,5-dimethoxy 4-iodoamphetamine 4-Iodo-2,5-dimethoxyamphetamine BDBM28582 CHEMBL6616 DTXSID7040520 MFCD05662244 Racemic DOI UNII-OOM10GW9UE 1-(2,5-dimethoxy-4-iodopheny)-2-aminopropane 2,5-Dimethoxy-4-iodophenylisopropylamine 9890AB BGMZUEKZENQUJY-UHFFFAOYSA-N DB-008006 InChI=1/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3 NCGC00162163-01 4-DOI AKOS015965128 CHEBI:64629 DOI,(-) Lopac0_000466 PDSP2_001367 RW3494 (+-)-DOI 2,5-Dimethoxy-4-iodoamphetamine 64584-34-5 Benzeneethanamine, 4-iodo-2,5-dimethoxy-alpha-methyl- CTK8J8388 FT-0666888 NCGC00015302-03 [125I]2,5-dimethoxy-4-iodoamphetamine 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine AC1L1B0E C11H16INO2 DOI KB-214892 OOM10GW9UE 4-Iodo-2,5-dimethoxy-alpha-methylbenzeneethanamine AX8051181 DOI-P LS-176383 QC-2023 [ Show all ]
Inchi Key	BGMZUEKZENQUJY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
PubChem CID	1229
ChEMBL	CHEMBL6616
IUPHAR	147
BindingDB	28582
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1000.0 nM	PMID7682702	BindingDB

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