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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Adenosine receptor A1
Species	Rattus norvegicus (Rat)
Gene	Adora1
Synonym	A1 receptor A1-AR A1R adenosine receptor A1 RDC7
Disease	N/A for non-human GPCRs
Length	326
Amino acid sequence	MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
UniProt	P25099
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL318
IUPHAR	18
DrugBank	N/A

Ligand

Name	amisulpride
Molecular formula	C17H27N3O4S
IUPAC name	4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
Molecular weight	369.48
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.5
Synonyms	NSC_2159 AS-13890 SC-23161 C-21104 Solian, Amisulpride CCG-222437 Tox21_113392_1 D07310 DSSTox_GSID_42613 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-ethylsulfonyl-2-methoxybenzamide HMS2235M16 I06-0334 ABP000597 MFCD00866691 NCGC00092310-01 Amisulpride/ Amisulpridum [INN-Latin] PubChem18224 BCPP000404 SMR000449309 CAS-71675-85-9 STK635172 CHEMBL243712 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide EINECS 275-831-7 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide HMS3369K09 AB0008029 L000106 AKOS005567252 W-104511 MLS001424039 Amisulpride [INN:BAN] NCGC00092310-04 APD421 SAM001246639 BG0361 Solian (TN) CCG-100860 SW197490-3 CTK8B3282 Deniban (TN) 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide GTPL963 675A859 HMS3713N06 AB00639933_10 LS41262 Amisulprida MolPort-029-999-733 Amisulpride, British Pharmacopoeia (BP) Reference Standard NSC-760085 NTJOBXMMWNYJFB-UHFFFAOYSA-N BCP02089 SCHEMBL34126 C17H27N3O4S SR-01000759303 CHEBI:64045 Tox21_501133 DAN 2163 4-amino-5-(ethanesulfonyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide DSSTox_RID_80058 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide HMS3263D07 K214 AC-6820 MLS000758258 Amisulpride (INN) NCGC00092310-02 Amisulpride; AN-6961 RL04735 BDBM81790 Socian CAS_71675-85-9 STL454297 CPD000449309 DB06288 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide FC0018 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide HMS3393K10 AB00639933-07 LP01133 Aminosultopride MLS006011769 Amisulpride [INN] NCGC00092310-06 NSC760085 API0005392 SAM001246966 BRD-A60197193-001-05-4 Solian, 71675-85-9 CCG-220622 Tox21_113392 D03ELL (plusmn)-amisulpride DSSTox_CID_22613 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide HMS2051K10 71675-85-9 HY-14545 AB1009624 MCULE-4239265090 Amisulprida [INN-Spanish] NC00110 Amisulpride, European Pharmacopoeia (EP) Reference Standard Pharmakon1600-01502285 BCP9000294 SL-91.1077 CA0133 SR-01000759303-5 DAN-2163 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-anisamid DTXSID5042613 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzenecarboximidic acid HMS3268L09 A837282 KS-00000XK6 AC1L1D1X MLS000759450 Amisulpride for system suitability, European Pharmacopoeia (EP) Reference Standard NCGC00092310-03 Amisulpridum ANW-42197 S1280 Benzamide, 4-amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy- Solian CC-24086 Sulpitac CS-1791 Deniban 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide FT-0630805 4-azanyl-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide HMS3657E11 AB00639933-09 LS-25532 Amisulpiride MolPort-003-983-463 Amisulpride, >=98% (HPLC) NCGC00261818-01 [ Show all ]
Inchi Key	NTJOBXMMWNYJFB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
PubChem CID	2159
ChEMBL	CHEMBL243712
IUPHAR	963
BindingDB	81790
DrugBank	DB06288
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID8996185	BindingDB

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