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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Ghrhr
Synonym	Ghrfr GHRH receptor GRF receptor GRFR Growth hormone-releasing factor receptor
Disease	N/A for non-human GPCRs
Length	464
Amino acid sequence	MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProt	Q02644
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3709
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL274599
Molecular formula	C28H34N4O2
IUPAC name	2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]-2-methylpropanamide
Molecular weight	458.606
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	3.7
Synonyms	L-162752 1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1H-indene-1,4''-(hexahydropyridine)]-1-ylethyl]-2-amino-2-methylpropanamide BDBM50069108 1-{[(2R)-1-{2,3-dihydrospiro[indene-1,4''-piperidine]-1''-yl}-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium SCHEMBL2578898 BDBM50403630 CHEMBL558802 1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1H-indene-1,4''-(hexahydropyridine)]-1-yl-(1R)-ethyl]-2-amino-2-methylpropanamide [ Show all ]
Inchi Key	NQEGSKXLUMFKJZ-XMMPIXPASA-N
Inchi ID	InChI=1S/C28H34N4O2/c1-27(2,29)26(34)31-24(17-20-18-30-23-10-6-4-8-21(20)23)25(33)32-15-13-28(14-16-32)12-11-19-7-3-5-9-22(19)28/h3-10,18,24,30H,11-17,29H2,1-2H3,(H,31,34)/t24-/m1/s1
PubChem CID	9890375
ChEMBL	CHEMBL274599
IUPHAR	N/A
BindingDB	50069108, 50403630
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14.0 nM	N/A	BindingDB

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