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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL137801
Molecular formula	C23H22FNO3
IUPAC name	6-[6-(4-fluorophenyl)-4-phenylpyridin-2-yl]oxyhexanoic acid
Molecular weight	379.431
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.1
Synonyms	Hexanoic acid, 6-[[6-(4-fluorophenyl)-4-phenyl-2-pyridinyl]oxy]- ACMC-20n0ub BGDZTYGXZZTYSF-UHFFFAOYSA-N 141747-54-8 CTK0B6613 6-[6-(4-Fluoro-phenyl)-4-phenyl-pyridin-2-yloxy]-hexanoic acid AKOS030603412 SCHEMBL6760753 DTXSID60438744 6-[[4-Phenyl-6-(4-fluorophenyl)pyridin-2-yl]oxy]hexanoic acid BDBM50001665 6-[(6-(4-fluorophenyl)-4-phenyl-2-pyridinyl)oxy]-hexanoic acid [ Show all ]
Inchi Key	BGDZTYGXZZTYSF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H22FNO3/c24-20-12-10-18(11-13-20)21-15-19(17-7-3-1-4-8-17)16-22(25-21)28-14-6-2-5-9-23(26)27/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,26,27)
PubChem CID	10362331
ChEMBL	CHEMBL137801
IUPHAR	N/A
BindingDB	50001665
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID1333012	BindingDB,ChEMBL
IC50	30.0 nM	PMID1333012	BindingDB,ChEMBL

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