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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392176
Molecular formula	C18H12BrNO6
IUPAC name	6-bromo-8-[(2-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight	418.199
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.8
Synonyms	BDBM50436005 4-Oxo-6-bromo-8-(2-methoxybenzoylamino)-4H-1-benzopyran-2-carboxylic acid
Inchi Key	NFUILGBRJQDWLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H12BrNO6/c1-25-14-5-3-2-4-10(14)17(22)20-12-7-9(19)6-11-13(21)8-15(18(23)24)26-16(11)12/h2-8H,1H3,(H,20,22)(H,23,24)
PubChem CID	71733845
ChEMBL	CHEMBL2392176
IUPHAR	N/A
BindingDB	50436005
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1659.59 nM	PMID23713606	ChEMBL
EC50	1660.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	91.0 %	PMID23713606	ChEMBL
Ki	331.0 nM	PMID23888932	BindingDB,ChEMBL

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