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GPCR

NameRhodopsin
SpeciesBos taurus (Bovine)
GeneRHO
SynonymN/A
DiseaseN/A for non-human GPCRs
Length348
Amino acid sequenceMNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA
UniProtP02699
Protein Data Bank2i35, 2j4y, 2ped, 3c9l, 3c9m, 2hpy, 2g87, 1u19, 1ln6, 1l9h, 1jfp, 1hzx, 1gzm, 1f88, 2x72, 3dqb, 3oax, 3pqr, 6fkd, 6fkc, 6fkb, 6fka, 6fk9, 6fk8, 6fk7, 6fk6, 5wkt, 5te5, 5en0, 5dys, 4x1h, 4pxf, 4j4q, 4a4m, 3pxo, 6fuf
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 2i35.
BioLiPBL0058001,BL0058005, BL0144059,BL0144060,BL0144061,, BL0144063, BL0149211, BL0186942,BL0186949, BL0186943,BL0186944,BL0186945,, BL0186947,BL0186953, BL0186948,BL0186954, BL0193496, BL0193497, BL0144058, BL0144057, BL0125584, BL0091202,BL0091203,BL0091204,, BL0091206,BL0091210, BL0095323,BL0095324,BL0095325,, BL0095326,BL0095330, BL0096347, BL0099220,BL0099221, BL0107380,BL0107381,BL0107382,, BL0107384,BL0107388, BL0125583, BL0193498, BL0194274, BL0219382, BL0398941, BL0409985, BL0409986, BL0409987, BL0409988, BL0409989, BL0409990, BL0409991, BL0409992, BL0372701, BL0354047, BL0354046, BL0219383, BL0259697, BL0259698,BL0259699,BL0259700,, BL0259702, BL0291136, BL0291137, BL0329157, BL0329158,BL0329159, BL0354035, BL0428638, BL0057997,BL0057998,BL0057999,, BL0032596, BL0398940, BL0012775,BL0012777, BL0012776,BL0012778, BL0018454,BL0018461, BL0018455,BL0018456,BL0018457,, BL0018459,BL0018467, BL0021853,BL0021854,BL0021855,, BL0021857,BL0021861, BL0025799, BL0031623,BL0031624,BL0031625,, BL0031627,BL0031631
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5739
IUPHARN/A
DrugBankN/A

Ligand

Name11-cis-Retinal
Molecular formulaC20H28O
IUPAC name(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal
Molecular weight284.443
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP6.2
Synonyms(5Z,11Z)-Retinal
91058V6HCH
DTXSID80415057
SCHEMBL8325392
(11Z)-Retinal
[ Show all ]
Inchi KeyNCYCYZXNIZJOKI-IOUUIBBYSA-N
Inchi IDInChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
PubChem CID5280490
ChEMBLCHEMBL1255087
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity100.0 %PMID21309593ChEMBL

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