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GPCR

NameG-protein coupled receptor 182
SpeciesHomo sapiens (Human)
GeneGPR182
SynonymNOW
L1-R
GPR182
Gpcr22
Gpcr17
[ Show all ]
DiseaseN/A
Length404
Amino acid sequenceMSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProtO15218
Protein Data BankN/A
GPCR-HGmod modelO15218
3D structure modelThis predicted structure model is from GPCR-EXP O15218.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4356
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL195275
Molecular formulaC24H30N4O6
IUPAC name1-N',8-N'-bis(2-phenoxyacetyl)octanedihydrazide
Molecular weight470.526
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP2.9
SynonymsN/A
Inchi KeyNARZHMQOGSVBOJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H30N4O6/c29-21(25-27-23(31)17-33-19-11-5-3-6-12-19)15-9-1-2-10-16-22(30)26-28-24(32)18-34-20-13-7-4-8-14-20/h3-8,11-14H,1-2,9-10,15-18H2,(H,25,29)(H,26,30)(H,27,31)(H,28,32)
PubChem CID11420013
ChEMBLCHEMBL195275
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Affinity20.0 %PMID15943480ChEMBL

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