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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3641733
Molecular formula	C16H20N4O3
IUPAC name	4,6-dimethoxy-N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight	316.361
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	1.7
Synonyms	US8802673, 183 BDBM129541 SCHEMBL12610076
Inchi Key	BEDHMXIJNIYXFG-ZDUSSCGKSA-N
Inchi ID	InChI=1S/C16H20N4O3/c1-21-14-9-15(22-2)20-16(19-14)18-12-5-3-11(4-6-12)13-10-17-7-8-23-13/h3-6,9,13,17H,7-8,10H2,1-2H3,(H,18,19,20)/t13-/m0/s1
PubChem CID	68325759
ChEMBL	CHEMBL3641733
IUPHAR	N/A
BindingDB	129541
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	9.4 nM	, None	BindingDB,ChEMBL

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