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GPCR

NameProstaglandin D2 receptor 2
SpeciesMus musculus (Mouse)
GenePtgdr2
SynonymPGD2 receptor
Gpr44
G-protein coupled receptor 44
G protein-coupled receptor 44
DP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length382
Amino acid sequenceMANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProtQ9Z2J6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2291
IUPHAR339
DrugBankN/A

Ligand

NameSpiro-indolinone analogue, 89
Molecular formulaC20H17ClN2O4
IUPAC name2-(1'-benzyl-5-chloro-2,2'-dioxospiro[indole-3,4'-pyrrolidine]-1-yl)acetic acid
Molecular weight384.816
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP1.7
SynonymsBDBM21597
SCHEMBL2480425
2-{1''-benzyl-5-chloro-1,2-dihydrospiro[indole-3,3''-pyrrolidine]-2,5''-dione}acetic acid
CHEMBL258751
Inchi KeyBDWQUHFLKUXBHZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H17ClN2O4/c21-14-6-7-16-15(8-14)20(19(27)23(16)11-18(25)26)9-17(24)22(12-20)10-13-4-2-1-3-5-13/h1-8H,9-12H2,(H,25,26)
PubChem CID24776296
ChEMBLCHEMBL258751
IUPHARN/A
BindingDB21597
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki480.0 nMPMID18318469BindingDB,ChEMBL

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