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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL39442
Molecular formula	C18H28ClN3O3
IUPAC name	4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(3-methyl-2-oxobutoxy)benzamide
Molecular weight	369.89
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.4
Synonyms	BDBM50023817 MSCZCXPVLRFFCL-UHFFFAOYSA-N 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(3-methyl)-butan-2-on-1-yl]oxybenzamide 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(3-methyl-2-oxo-butoxy)-benzamide SCHEMBL10547197 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(3-methyl)-butan-2- on-1-yl]oxybenzamide [ Show all ]
Inchi Key	MSCZCXPVLRFFCL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H28ClN3O3/c1-5-22(6-2)8-7-21-18(24)13-9-14(19)15(20)10-17(13)25-11-16(23)12(3)4/h9-10,12H,5-8,11,20H2,1-4H3,(H,21,24)
PubChem CID	14116895
ChEMBL	CHEMBL39442
IUPHAR	N/A
BindingDB	50023817
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<40.0 mg.kg-1	PMID3397992	ChEMBL
IC50	<1000.0 nM	PMID3397992	BindingDB,ChEMBL

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