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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL219308
Molecular formula	C26H32F3N3O5
IUPAC name	3-[[4-[[heptan-3-yl-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]methyl]benzoyl]amino]propanoic acid
Molecular weight	523.553
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	5.3
Synonyms	3-(4-((1-(heptan-3-yl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid BDBM50202035
Inchi Key	BDIVWXZQXHNQRQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H32F3N3O5/c1-3-5-6-21(4-2)32(25(36)31-20-11-13-22(14-12-20)37-26(27,28)29)17-18-7-9-19(10-8-18)24(35)30-16-15-23(33)34/h7-14,21H,3-6,15-17H2,1-2H3,(H,30,35)(H,31,36)(H,33,34)
PubChem CID	44418928
ChEMBL	CHEMBL219308
IUPHAR	N/A
BindingDB	50202035
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	141.0 nM	PMID17201415	BindingDB,ChEMBL

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