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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL372570
Molecular formulaC27H29N5O2
IUPAC name1-(4-phenylmethoxyphenyl)-3-[1-(2-pyrrolidin-1-ylethyl)indazol-6-yl]urea
Molecular weight455.562
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.1
Synonyms1-(4-Benzyloxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]-urea
BDBM50167549
SCHEMBL6069760
Inchi KeyMKWZMWRFPPUXEB-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H29N5O2/c33-27(29-23-10-12-25(13-11-23)34-20-21-6-2-1-3-7-21)30-24-9-8-22-19-28-32(26(22)18-24)17-16-31-14-4-5-15-31/h1-3,6-13,18-19H,4-5,14-17,20H2,(H2,29,30,33)
PubChem CID11518159
ChEMBLCHEMBL372570
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50113.0 nMPMID15911251ChEMBL

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