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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-1 angiotensin II receptor
Species	Sus scrofa (Pig)
Gene	AGTR1
Synonym	Angiotensin II type-1 receptor AT1
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MILNSSTEDSIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKIADIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSENGSSSTKKSAPCTEVE
UniProt	P30555
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5743
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL239393
Molecular formula	C23H32N2O5S2
IUPAC name	butyl N-[3-[4-[2-(dimethylamino)-2-oxoethyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate
Molecular weight	480.638
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	5.0
Synonyms	butyl 3-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-5-isobutylthiophen-2-ylsulfonylcarbamate N-butyloxycarbonyl-3-[4-(N,N-dimethylcarbamoylmethyl)phenyl]-5-iso-butylthiophene-2-sulfonamide BDBM50221297
Inchi Key	MJVHOJCMTONSPL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H32N2O5S2/c1-6-7-12-30-23(27)24-32(28,29)22-20(15-19(31-22)13-16(2)3)18-10-8-17(9-11-18)14-21(26)25(4)5/h8-11,15-16H,6-7,12-14H2,1-5H3,(H,24,27)
PubChem CID	9805192
ChEMBL	CHEMBL239393
IUPHAR	N/A
BindingDB	50221297
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.0 nM	PMID18599297	BindingDB,ChEMBL

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