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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Relaxin receptor 2
Species	Homo sapiens (Human)
Gene	RXFP2
Synonym	RXFPR2 RXFP2 relaxin/insulin like family peptide receptor 2 relaxin receptor 2 Relaxin family peptide receptor 2 LGR8 Leucine-rich repeat-containing G-protein coupled receptor 8 leucine-rich repeat-containing G protein-coupled receptor 8 INSL3 receptor GPR106 G-protein coupled receptor affecting testicular descent G-protein coupled receptor 106 [ Show all ]
Disease	N/A
Length	754
Amino acid sequence	MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProt	Q8WXD0
Protein Data Bank	2m96
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2m96.
BioLiP	BL0278456
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628482
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS001116560
Molecular formula	C21H19N3O6S
IUPAC name	5-[(5,7-dioxopyrrolo[3,4-b]pyridin-6-yl)methyl]-2-methoxy-N-[(5-methylfuran-2-yl)methyl]benzenesulfonamide
Molecular weight	441.458
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	1.6
Synonyms	SMR000630009 5-[(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methyl]-2-methoxy-N-[(5-methyl-2-furyl)methyl]-1-benzenesulfonamide ZINC9226309 CHEMBL1545457 MolPort-007-771-522 AKOS001554892 HMS2958K18 [ Show all ]
Inchi Key	BCZHYRSLVLVNSI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H19N3O6S/c1-13-5-7-15(30-13)11-23-31(27,28)18-10-14(6-8-17(18)29-2)12-24-20(25)16-4-3-9-22-19(16)21(24)26/h3-10,23H,11-12H2,1-2H3
PubChem CID	20923178
ChEMBL	CHEMBL1545457
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	24529.7 nM	PubChem BioAssay data set	ChEMBL

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