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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	2-oxoglutarate receptor 1
Species	Rattus norvegicus (Rat)
Gene	Oxgr1
Synonym	P2Y purinoceptor 15 P2RY15 oxoglutarate receptor GPR99 GPR80 G-protein coupled receptor 80 G protein-coupled receptor 99 G protein-coupled receptor 80 Alpha-ketoglutarate receptor 1 2-oxoglutarate receptor 1 P2Y15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	337
Amino acid sequence	MIETLDSPANDSDFLDYITALENCTDEQISFKMQYLPVIYSIIFLVGFPGNTVAISIYVFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFGFHFNLYSSILFLTCFSLFRYIVIIHPMSCFSIQKTRWAVVACAGVWVISLVAVMPMTFLITSTTRTNRSACLDLTSSDDLTTIKWYNLILTATTFCLPLLIVTLCYTTIISTLTHGPRTHSCFKQKARRLTILLLLVFYVCFLPFHILRVIRIESRLLSISCSIESHIHEAYIVSRPLAALNTFGNLLLYVVVSNNFQQAFCSAVRCKAIGDLEQAKKDSCSNNP
UniProt	Q6Y1R5
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2325
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL609186
Molecular formula	C14H20N6O4
IUPAC name	(2S,3S,4R)-5-(6-aminopurin-9-yl)-N-butyl-3,4-dihydroxyoxolane-2-carboxamide
Molecular weight	336.352
Hydrogen bond acceptor	8
Hydrogen bond donor	4
XlogP	0.2
Synonyms	BDBM50369155
Inchi Key	MIGNEXCHXYOFBR-JDSSLJPYSA-N
Inchi ID	InChI=1S/C14H20N6O4/c1-2-3-4-16-13(23)10-8(21)9(22)14(24-10)20-6-19-7-11(15)17-5-18-12(7)20/h5-6,8-10,14,21-22H,2-4H2,1H3,(H,16,23)(H2,15,17,18)/t8-,9+,10-,14?/m0/s1
PubChem CID	49797674
ChEMBL	CHEMBL609186
IUPHAR	N/A
BindingDB	50369155
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	17.0 nM	PMID11170630	BindingDB,ChEMBL

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