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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Mus musculus (Mouse)
Gene	Mchr1
Synonym	SLC-1 {ECO:0000303\|PubMed:11159839} MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	Q8JZL2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4730
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL186333
Molecular formula	C21H21F3N2O4
IUPAC name	N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-3-yl]-3-(trifluoromethoxy)benzamide
Molecular weight	422.404
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.3
Synonyms	BDBM50168539 N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3-trifluoromethoxy-benzamide
Inchi Key	MGFAGHHUZJKCJS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H21F3N2O4/c22-21(23,24)30-17-5-1-3-15(10-17)20(27)25-16-4-2-8-26(12-16)11-14-6-7-18-19(9-14)29-13-28-18/h1,3,5-7,9-10,16H,2,4,8,11-13H2,(H,25,27)
PubChem CID	44397425
ChEMBL	CHEMBL186333
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	540.0 nM	PMID15950463	ChEMBL

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