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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Nociceptin receptor
Species	Mus musculus (Mouse)
Gene	Oprl1
Synonym	NOP receptor NOP-r NOPr OP4 ORGC Orphanin FQ receptor NOCIR nociceptin/orphanin FQ receptor nociceptin receptor ORL1 N/OFQ receptor MOR-C KOR-3 kappa3-related opioid receptor Kappa-type 3 opioid receptor K3 opiate receptor XOR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	367
Amino acid sequence	MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProt	P35377
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3621
IUPHAR	320
DrugBank	N/A

Ligand

Name	CHEMBL411168
Molecular formula	C62H102N22O15
IUPAC name	(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[2-[[(2S,3R)-3-hydroxy-2-[[(2S)-2-[[2-[[2-[[2-[(4-methylphenyl)methylamino]acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanoyl]amino]acetyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Molecular weight	1395.64
Hydrogen bond acceptor	20
Hydrogen bond donor	22
XlogP	-6.6
Synonyms	N/A
Inchi Key	MEPSQOOWEQUSDG-JDSHJPIKSA-N
Inchi ID	InChI=1S/C62H102N22O15/c1-35-20-22-40(23-21-35)29-70-30-47(87)73-31-48(88)74-32-50(90)78-45(28-39-14-6-5-7-15-39)58(97)84-51(38(4)86)60(99)75-33-49(89)76-36(2)53(92)80-44(19-13-27-72-62(68)69)56(95)82-42(17-9-11-25-64)57(96)83-46(34-85)59(98)77-37(3)54(93)81-43(18-12-26-71-61(66)67)55(94)79-41(52(65)91)16-8-10-24-63/h5-7,14-15,20-23,36-38,41-46,51,70,85-86H,8-13,16-19,24-34,63-64H2,1-4H3,(H2,65,91)(H,73,87)(H,74,88)(H,75,99)(H,76,89)(H,77,98)(H,78,90)(H,79,94)(H,80,92)(H,81,93)(H,82,95)(H,83,96)(H,84,97)(H4,66,67,71)(H4,68,69,72)/t36-,37-,38+,41-,42-,43-,44-,45-,46-,51-/m0/s1
PubChem CID	10844105
ChEMBL	CHEMBL411168
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2511.89 nM	PMID10956188	ChEMBL

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