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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Mu-type opioid receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRM1
Synonym	M-OR-1 MOR-1
Disease	N/A for non-human GPCRs
Length	98
Amino acid sequence	YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProt	P97266
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4354
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL294616
Molecular formula	C30H39N5O7S2
IUPAC name	(4S,7R,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
Molecular weight	645.79
Hydrogen bond acceptor	10
Hydrogen bond donor	7
XlogP	-0.6
Synonyms	BDBM50001683 MCMMCRYPQBNCPH-DVKRWUGUSA-N 13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
Inchi Key	MCMMCRYPQBNCPH-DVKRWUGUSA-N
Inchi ID	InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1
PubChem CID	44299404
ChEMBL	CHEMBL294616
IUPHAR	N/A
BindingDB	50001683
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7300.0 nM	PMID13678399, PMID8021915	BindingDB,ChEMBL
Emax	51.4 -	PMID10571174	ChEMBL
Emax	51.4 nM	PMID10612597	ChEMBL
IC50	<1000.0 nM	PMID7853350, PMID8071934	BindingDB,ChEMBL
IC50	1760.0 nM	PMID7996538	BindingDB,ChEMBL
IC50	2720.0 nM	PMID20560643, PMID20617791	BindingDB,ChEMBL
IC50	5500.0 nM	PMID1851843	BindingDB,ChEMBL
IC50	7300.0 nM	PMID8831778, PMID7739011, PMID8289188, PMID12166947, PMID8642567, PMID8035418, PMID1648137, PMID8201592, PMID9057856	BindingDB,ChEMBL
IC50	10000.0 nM	PMID2828622	BindingDB,ChEMBL
IC50	11600.0 nM	PMID14998329	BindingDB,ChEMBL
Kd	577.0 nM	PMID10571174, PMID10612597	BindingDB,ChEMBL
Ki	810.0 nM	PMID1333014, PMID1315870	BindingDB,ChEMBL
Ratio	1800.0 -	PMID8201592	ChEMBL

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