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Name | Trace amine-associated receptor 1 |
---|---|
Species | Mus musculus (Mouse) |
Gene | Taar1 |
Synonym | TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1 |
Disease | N/A for non-human GPCRs |
Length | 332 |
Amino acid sequence | MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL |
UniProt | Q923Y8 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4908 |
IUPHAR | 364 |
DrugBank | N/A |
Name | CHEMBL3701947 |
---|---|
Molecular formula | C20H21N3O |
IUPAC name | 2-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]quinolin-8-amine |
Molecular weight | 319.408 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 3.2 |
Synonyms | US8802673, 48 BDBM129406 SCHEMBL12609737 |
Inchi Key | MCJDIUWMTZVQQI-LJQANCHMSA-N |
Inchi ID | InChI=1S/C20H21N3O/c1-14-5-6-16-3-2-4-18(20(16)22-14)23-17-9-7-15(8-10-17)19-13-21-11-12-24-19/h2-10,19,21,23H,11-13H2,1H3/t19-/m1/s1 |
PubChem CID | 68325516 |
ChEMBL | CHEMBL3701947 |
IUPHAR | N/A |
BindingDB | 129406 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 121.8 nM | , None | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417