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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesHomo sapiens (Human)
GeneHTR4
Synonym5-HT-4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
5-HT4 receptor
5-HT4
serotonin receptor 4
DiseaseN/A
Length388
Amino acid sequenceMDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProtQ13639
Protein Data BankN/A
GPCR-HGmod modelQ13639
3D structure modelThis predicted structure model is from GPCR-EXP Q13639.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1875
IUPHAR9
DrugBankBE0000084

Ligand

NameCHEMBL2440451
Molecular formulaC22H31N3O3
IUPAC nameN-[(1-butylpiperidin-4-yl)methyl]-7-hydroxy-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
Molecular weight385.508
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.3
SynonymsBDBM50442805
Inchi KeyBBTVQUWEONDCQJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H31N3O3/c1-2-3-9-24-11-7-16(8-12-24)15-23-21(27)20-18-6-5-17(26)14-19(18)25-10-4-13-28-22(20)25/h5-6,14,16,26H,2-4,7-13,15H2,1H3,(H,23,27)
PubChem CID73354085
ChEMBLCHEMBL2440451
IUPHARN/A
BindingDB50442805
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki794.33 nMPMID24113240ChEMBL

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