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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	1,3-Diethyl-8-phenylxanthine
Molecular formula	C15H16N4O2
IUPAC name	1,3-diethyl-8-phenyl-7H-purine-2,6-dione
Molecular weight	284.319
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.9
Synonyms	SR-01000075182-1 1,3-Dithyl-8-phenylxanthine AC1L1B8H GTPL445 PDSP1_000323 1,3-Diethyl-3,9-dihydro-8-phenyl-1H-purine-2,6-dione 2KCV39GKGL AKOS027378654 D07HKU Lopac0_000125 PDSP2_000321 1,3-diethyl-8-phenyl-7H-purine-2,6-dione 8-Phenyl-1,3-diethylxanthine CAS_1328 EU-0100125 NCGC00093616-01 SCHEMBL1321894 UNII-2KCV39GKGL 1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-phenyl- AC1Q312F CHEMBL11348 L001207 PDSP1_000326 1,3-Diethyl-8-phenyl-1H-purine-2,6(3H,7H)-dione BDBM81971 D0BD8N NCGC00014999-01 PDSP2_000324 CCG-204220 FT-0606658 NSC_1328 SR-01000075182 ZINC9229229 1H-Purine-2,6-dione,1,3-diethyl-3,9-dihydro-8-phenyl- AC1Q6LCB CTK5E2202 Lopac-A-003 PDSP1_000991 1,3-Diethyl-8-phenyl-3,7-dihydro-purine-2,6-dione 75922-48-4 C-48797 DEPX NCGC00014999-02 PDSP2_000975 [ Show all ]
Inchi Key	LVSWNSHUTPWCNF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H16N4O2/c1-3-18-13-11(14(20)19(4-2)15(18)21)16-12(17-13)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3,(H,16,17)
PubChem CID	1328
ChEMBL	CHEMBL11348
IUPHAR	445
BindingDB	81971
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	446.7 nM	PubChem BioAssay data set	ChEMBL

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