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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Corticotropin-releasing factor receptor 1
Species	Homo sapiens (Human)
Gene	CRHR1
Synonym	CRHR CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor Corticotropin-releasing hormone receptor 1 CRF 1 receptor CRF-R CRF-R-1 CRF-R1 CRF-R1alpha CRF-RA [ Show all ]
Disease	Major depressive disorder; Severe mood disorder Depression; Anxiety Depression Irritable bowel syndrome Anxiety disorder; Depression Anxiety disorder Alcohol use disorders; Major depressive disorder Staphylococcus aureus infection [ Show all ]
Length	444
Amino acid sequence	MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProt	P34998
Protein Data Bank	4z9g, 4k5y
GPCR-HGmod model	P34998
3D structure model	This structure is from PDB ID 4z9g.
BioLiP	BL0350036,BL0350037,BL0350038, BL0251208
Therapeutic Target Database	T45262
ChEMBL	CHEMBL1800
IUPHAR	212
DrugBank	BE0008658

Ligand

Name	CHEMBL115119
Molecular formula	C16H10Cl3N
IUPAC name	4-chloro-8-(2,4-dichlorophenyl)-2-methylquinoline
Molecular weight	322.613
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	6.1
Synonyms	2-Methyl-4-chloro-8-(2,4-dichlorophenyl)quinoline BBNQCAXGODUUPF-UHFFFAOYSA-N 4-Chloro-8-(2,4-dichloro-phenyl)-2-methyl-quinoline BDBM50132960 2-methyl-4-chloro-8-(2',4'-dichlorophenyl)quinoline SCHEMBL5246749 [ Show all ]
Inchi Key	BBNQCAXGODUUPF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H10Cl3N/c1-9-7-14(18)13-4-2-3-12(16(13)20-9)11-6-5-10(17)8-15(11)19/h2-8H,1H3
PubChem CID	11759092
ChEMBL	CHEMBL115119
IUPHAR	N/A
BindingDB	50132960
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.0 nM	PMID12951129	BindingDB,ChEMBL

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