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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL139325
Molecular formula	C39H33Cl2N5O5S
IUPAC name	N-[2-[4-[[1-(5-benzamido-2-chlorophenyl)-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-2-chlorobenzamide
Molecular weight	754.683
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	8.1
Synonyms	N-(2-Chlorobenzoyl)-4'-[[3-butyl-5-oxo-1-[2-chloro-5-(benzoylamino)phenyl]-1H-1,2,4-triazol-4(5H)-yl]methyl]-1,1'-biphenyl-2-sulfonamide N-(3-{3-Butyl-4-[2''-(2-chloro-benzoylsulfamoyl)-biphenyl-4-ylmethyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-4-chloro-phenyl)-benzamide SCHEMBL9565975 BDBM50035465
Inchi Key	BBNLIOWRWDAPAV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C39H33Cl2N5O5S/c1-2-3-17-36-43-46(34-24-29(22-23-33(34)41)42-37(47)28-11-5-4-6-12-28)39(49)45(36)25-26-18-20-27(21-19-26)30-13-8-10-16-35(30)52(50,51)44-38(48)31-14-7-9-15-32(31)40/h4-16,18-24H,2-3,17,25H2,1H3,(H,42,47)(H,44,48)
PubChem CID	10010311
ChEMBL	CHEMBL139325
IUPHAR	N/A
BindingDB	50035465
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.1 nM	PMID7799397	BindingDB,ChEMBL

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