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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL159093
Molecular formula	C24H20ClF3N2O6
IUPAC name	3-chloro-N-[(E)-[3,5-dimethoxy-4-[[4-(trifluoromethoxy)phenyl]methoxy]phenyl]methylideneamino]-4-hydroxybenzamide
Molecular weight	524.877
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	5.7
Synonyms	BDBM50110080 SCHEMBL9072211 3-Chloro-4-hydroxy-benzoic acid [1-[3,5-dimethoxy-4-(4-trifluoromethoxy-benzyloxy)-phenyl]-meth-(E)-ylidene]-hydrazide
Inchi Key	ACVBJOZEKSRNDC-XKJRVUDJSA-N
Inchi ID	InChI=1S/C24H20ClF3N2O6/c1-33-20-9-15(12-29-30-23(32)16-5-8-19(31)18(25)11-16)10-21(34-2)22(20)35-13-14-3-6-17(7-4-14)36-24(26,27)28/h3-12,31H,13H2,1-2H3,(H,30,32)/b29-12+
PubChem CID	44373676
ChEMBL	CHEMBL159093
IUPHAR	N/A
BindingDB	50110080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	180.0 nM	PMID11844695	BindingDB,ChEMBL

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