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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProt	Q91ZY1
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4468
IUPHAR	265
DrugBank	N/A

Ligand

Name	CHEMBL493104
Molecular formula	C22H22N6
IUPAC name	4-[2-amino-6-(4-methylpiperazin-1-yl)-5-phenylpyrimidin-4-yl]benzonitrile
Molecular weight	370.46
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.1
Synonyms	SCHEMBL2165268
Inchi Key	LQPZZGLWIAIMKL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H22N6/c1-27-11-13-28(14-12-27)21-19(17-5-3-2-4-6-17)20(25-22(24)26-21)18-9-7-16(15-23)8-10-18/h2-10H,11-14H2,1H3,(H2,24,25,26)
PubChem CID	25131233
ChEMBL	CHEMBL493104
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pKb	5.29 -	PMID18811133	ChEMBL

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