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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Mus musculus (Mouse)
Gene	Ptger3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype prostaglandin E receptor 3 prostanoid EP3 receptor
Disease	N/A for non-human GPCRs
Length	365
Amino acid sequence	MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProt	P30557
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4336
IUPHAR	342
DrugBank	N/A

Ligand

Name	acrylic acid derivative, 4
Molecular formula	C25H22N2O3
IUPAC name	(E)-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid
Molecular weight	398.462
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.0
Synonyms	SCHEMBL2975209 SCHEMBL2975215 CHEMBL595632 BDBM35855
Inchi Key	BAXFMLZOUPMNQW-ZHACJKMWSA-N
Inchi ID	InChI=1S/C25H22N2O3/c28-25(29)11-10-22-9-7-20(18-27-14-3-13-26-27)17-24(22)30-15-12-19-6-8-21-4-1-2-5-23(21)16-19/h1-11,13-14,16-17H,12,15,18H2,(H,28,29)/b11-10+
PubChem CID	10294290
ChEMBL	CHEMBL595632
IUPHAR	N/A
BindingDB	35855
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	73.0 nM	PMID19700331	BindingDB
IC50	73.0 nM	PMID19700331	ChEMBL
Ki	12.0 nM	PMID19700331	BindingDB,ChEMBL

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