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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	CHEMBL394468
Molecular formula	C9H10N2O2
IUPAC name	6-(prop-2-enylamino)pyridine-3-carboxylic acid
Molecular weight	178.191
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	6-(allylamino)nicotinic acid AKOS000216073 BDBM50414513
Inchi Key	LOLMTHLRZHBMAD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10N2O2/c1-2-5-10-8-4-3-7(6-11-8)9(12)13/h2-4,6H,1,5H2,(H,10,11)(H,12,13)
PubChem CID	28399894
ChEMBL	CHEMBL394468
IUPHAR	N/A
BindingDB	50414513
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	200.0 %	PMID19524438	ChEMBL
EC50	41.69 nM	PMID19524438	ChEMBL
EC50	42.0 nM	PMID19524438	BindingDB
EC50	70.79 nM	PMID17931863	ChEMBL

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