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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	Pharmakon1600-01500325 Bioperidolo KBioGR_000980 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone Prestwick3_000115 Brotopon Linton 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone S1920 C01814 McM-JR-1625 4763-EP2269989A1 Halol MolPort-000-883-311 4763-EP2292614A1 Haloperidol 1.0 mg/ml in Methanol DivK1c_000654 NCGC00015500-06 4763-EP2308867A2 Haloperidol, 1 Duraperidol NCGC00015500-14 52-86-8 Halopoidol Fortunan NCGC00023875-05 AB00052008_24 HMS2234P08 GTPL86 Novo-Peridol Aldo I14-13404 NSC757054 AN-41634 KBio2_001341 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Serenelfi SPECTRUM1500325 SR-01000003076-2 Tox21_300475 W-105791 KBio2_004958 Pms Haloperidol BPBio1_001231 KBioSS_002395 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone Probes2_000296 BSPBio_002096 LNEPOXFFQSENCJ-UHFFFAOYSA-N 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one CC-16450 MDMO-PPV 4763-EP2272972A1 CS-1971 NCGC00015500-01 4763-EP2295413A1 Haloperidol Intensol Dozix NCGC00015500-09 4763-EP2311803A1 Haloperidol, powder Einalon S (TN) NCGC00015500-17 A0H334 HMS1568G12 Galoperidol NCGC00023875-08 AC1L1G7K HMS3657I13 Haldol (TN) NSC-170973 Aloperidol IN1474 Pekuces Apo-Haloperidol SCHEMBL8264 Sigaperidol Spectrum4_000570 STL417208 Ulcolind ZINC537822 BIDD:GT0128 KBio3_001316 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone Prestwick1_000115 BRD-K67783091-003-03-6 L000288 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone R-1625 Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- LP00583 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCRIS 1630 MLS000028450 4763-EP2277872A1 Haloperidol (JP15/USP/INN) NCGC00015500-04 4763-EP2298776A1 Haloperidol [USAN:INN:BAN:JAN] DSSTox_RID_79117 NCGC00015500-12 4763-EP2316834A1 Haloperidolum [INN-Latin] Eukystol NCGC00023875-02 AB00052008-22 HMS2091J09 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone NCGC00261268-01 ACM1189986591 HSDB 3093 Halidol NSC170973 Aloperidolo [Italian] KB-79571 .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone Peridol Serenase SPBio_001236 SR-01000003076 Tox21_110162 Vesalium 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Phenolic epoxy resin Bioperidolo (TN) KBioGR_002390 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Prestwick_250 Brotopon (TN) Linton (TN) 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one SBI-0050565.P004 C21H23ClFNO2 McN-JR-1625 4763-EP2269990A1 Halopal CHEMBL54 MRF-0000027 4763-EP2295061A1 Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard Dozic NCGC00015500-07 4763-EP2308870A2 Haloperidol, European Pharmacopoeia (EP) Reference Standard Duraperidol (TN) NCGC00015500-15 61788-97-4 Halosten FT-0669100 NCGC00023875-06 AB2000375 HMS3261F08 H 1512 NSC 170973 Aloperidin I14-14165 Opera_ID_446 AOB5645 KBio2_002390 SC 170973 Sernas Spectrum2_001268 SR-01000003076-8 Tox21_500583 W0039 KBio2_006477 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] BRD-K67783091-001-04-8 Keselan 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone QTL1_000042 Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- Lopac-H-1512 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCG-36042 MFCD00051423 4763-EP2272973A1 Haloperidol (Haldol) D00136 NCGC00015500-02 4763-EP2295439A1 Haloperidol lactate DSSTox_CID_14150 NCGC00015500-10 4763-EP2311824A1 Haloperidol, United States Pharmacopeia (USP) Reference Standard EINECS 200-155-6 NCGC00015500-19 AB00052008 HMS1920D03 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone NCGC00023875-09 AC1Q77Z0 HMS3712G12 Haldol La NSC-615296 Aloperidolo InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 Peluces BDBM21398 Serenace Sigaperidol (TN) Spectrum5_000788 SW196557-4 Uliolind Pernox Biomol-NT_000035 KBio3_002869 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone Prestwick2_000115 BRN 0331267 Lealgin compositum 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone Resin epoxy C-35402 LS-48311 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Halojust CHEBI:5613 MLS001146904 4763-EP2277876A1 Haloperidol (JP17/USP/INN) DB00502 NCGC00015500-05 4763-EP2305260A1 Haloperidol [USAN:USP:INN:BAN:JAN] DTXSID4034150 NCGC00015500-13 5-21-02-00377 (Beilstein Handbook Reference) Halopidol Eukystol (TN) NCGC00023875-04 AB00052008_23 HMS2095G12 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone NINDS_000654 AKOS000280660 HY-14538 NSC615296 Aloperidon KBio1_000654 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine Serenase (TN) SPBio_002069 SR-01000003076-11 Tox21_110162_1 VU0239704-10 177716-59-5 Picroside-III BPBio1_000144 KBioSS_001341 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone Probes1_000255 BSPBio_000130 LNEPOXFFQSENCJ-UHFFFAOYSA- 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one CAS-52-86-8 MCULE-3693790133 4763-EP2272537A2 Haloperido cMAP_000037 N1910 4763-EP2295412A1 Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard Dozic (TN) NCGC00015500-08 4763-EP2311801A1 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material Einalon S NCGC00015500-16 Halosten (TN) FT-0697842 NCGC00023875-07 AC-19691 HMS3370H11 Haldol NSC 615296 Aloperidin (TN) IDI1_000654 Oprea1_509923 API0002885 KBio2_003909 SC-81035 Sernel Spectrum3_000448 ST50319916 TR-018722 WLN: T6NTJ A3VR DF& DQ DR DG BG0211 KBio2_007526 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone Prestwick0_000115 BRD-K67783091-001-05-5 Keselan (TN) 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) R 1625 Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- Lopac0_000583 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one CCG-39111 Mixidol 4763-EP2275420A1 Haloperidol (JP15/USP) D0D1AL NCGC00015500-03 4763-EP2298731A1 Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material DSSTox_GSID_34150 NCGC00015500-11 4763-EP2311837A1 Haloperidolum EU-0100583 NCGC00016234-01 AB00052008-21 HMS2089M15 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone NCGC00254503-01 AC250 HMS502A16 Haldol Solutab NSC-757054 Aloperidolo [DCIT] J6292F8L3D .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone Peluces (TN) Serenace (TN) SMR000058303 Spectrum_000861 Tocris-0931 UNII-J6292F8L3D [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID9406603, PMID10377229	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID9225287, PMID9686407	BindingDB
Ki	1500.0 nM	PMID9430133	BindingDB
Ki	2320.0 nM	PMID1347569	BindingDB
Ki	2511.88 nM	PMID7908055	BindingDB
Ki	4600.0 nM	PMID3139864	BindingDB
Ki	4700.0 nM	PMID25070422	BindingDB,ChEMBL

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