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GPCR

Name	D(1A) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd1
Synonym	D1 receptor D1A DADR Dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	Q61616
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3071
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	HMS502A16 Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one NSC-757054 J6292F8L3D CCG-39111 4763-EP2275420A1 Peluces (TN) KBio2_007526 D0D1AL 4763-EP2298731A1 Prestwick0_000115 Keselan (TN) DSSTox_GSID_34150 4763-EP2311837A1 R 1625 Lopac0_000583 EU-0100583 AB00052008-21 Mixidol gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone Haloperidol (JP15/USP) AC250 NCGC00015500-03 Haldol Solutab Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Aloperidolo [DCIT] .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone NCGC00015500-11 Haloperidolum BG0211 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone NCGC00016234-01 HMS2089M15 BRD-K67783091-001-05-5 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) NCGC00254503-01 Serenace Sigaperidol (TN) Spectrum5_000788 SW196557-4 Uliolind 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone Novo-Peridol I14-13404 C01814 4763-EP2269989A1 NSC757054 KBio2_001341 4763-EP2292614A1 Pharmakon1600-01500325 KBioGR_000980 DivK1c_000654 4763-EP2308867A2 Prestwick3_000115 Linton Duraperidol 52-86-8 S1920 McM-JR-1625 Fortunan Halol AB00052008_24 MolPort-000-883-311 GTPL86 Haloperidol 1.0 mg/ml in Methanol Aldo NCGC00015500-06 Haloperidol, 1 AN-41634 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- NCGC00015500-14 Halopoidol Bioperidolo 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone NCGC00023875-05 HMS2234P08 Brotopon Serenase (TN) SPBio_002069 SR-01000003076-11 Tox21_110162_1 VU0239704-10 BSPBio_002096 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one NSC-170973 IN1474 CC-16450 4763-EP2272972A1 Pekuces KBio2_004958 CS-1971 4763-EP2295413A1 Pms Haloperidol KBioSS_002395 Dozix 4763-EP2311803A1 Probes2_000296 LNEPOXFFQSENCJ-UHFFFAOYSA-N Einalon S (TN) A0H334 MDMO-PPV Galoperidol AC1L1G7K NCGC00015500-01 Haldol (TN) Haloperidol Intensol Aloperidol NCGC00015500-09 Haloperidol, powder Apo-Haloperidol NCGC00015500-17 HMS1568G12 BPBio1_001231 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone NCGC00023875-08 HMS3657I13 WLN: T6NTJ A3VR DF& DQ DR DG SC-81035 Sernel Spectrum3_000448 ST50319916 TR-018722 HSDB 3093 Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone NSC170973 KB-79571 CCRIS 1630 4763-EP2277872A1 Peridol KBio3_001316 4763-EP2298776A1 Prestwick1_000115 L000288 DSSTox_RID_79117 4763-EP2316834A1 R-1625 LP00583 Eukystol AB00052008-22 MLS000028450 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone Haloperidol (JP15/USP/INN) ACM1189986591 NCGC00015500-04 Halidol Haloperidol [USAN:INN:BAN:JAN] Aloperidolo [Italian] .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone NCGC00015500-12 Haloperidolum [INN-Latin] BIDD:GT0128 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone NCGC00023875-02 HMS2091J09 BRD-K67783091-003-03-6 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone NCGC00261268-01 Serenace (TN) SMR000058303 Spectrum_000861 Tocris-0931 UNII-J6292F8L3D 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one NSC 170973 I14-14165 C21H23ClFNO2 4763-EP2269990A1 Opera_ID_446 KBio2_002390 CHEMBL54 4763-EP2295061A1 Phenolic epoxy resin KBioGR_002390 Dozic 4763-EP2308870A2 Prestwick_250 Linton (TN) Duraperidol (TN) 61788-97-4 SBI-0050565.P004 McN-JR-1625 FT-0669100 Halopal AB2000375 MRF-0000027 H 1512 Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard Aloperidin NCGC00015500-07 Haloperidol, European Pharmacopoeia (EP) Reference Standard AOB5645 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- NCGC00015500-15 Halosten Bioperidolo (TN) 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one NCGC00023875-06 HMS3261F08 Brotopon (TN) Serenelfi SPECTRUM1500325 SR-01000003076-2 Tox21_300475 W-105791 HMS3712G12 Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone NSC-615296 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 CCG-36042 4763-EP2272973A1 Peluces KBio2_006477 D00136 4763-EP2295439A1 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] Keselan DSSTox_CID_14150 4763-EP2311824A1 QTL1_000042 Lopac-H-1512 EINECS 200-155-6 AB00052008 MFCD00051423 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone Haloperidol (Haldol) AC1Q77Z0 NCGC00015500-02 Haldol La Haloperidol lactate Aloperidolo NCGC00015500-10 Haloperidol, United States Pharmacopeia (USP) Reference Standard BDBM21398 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone NCGC00015500-19 HMS1920D03 BRD-K67783091-001-04-8 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone NCGC00023875-09 ZINC537822 SCHEMBL8264 Sigaperidol Spectrum4_000570 STL417208 Ulcolind HY-14538 C-35402 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone NSC615296 KBio1_000654 CHEBI:5613 4763-EP2277876A1 Pernox KBio3_002869 DB00502 4763-EP2305260A1 Prestwick2_000115 Lealgin compositum DTXSID4034150 5-21-02-00377 (Beilstein Handbook Reference) Resin epoxy LS-48311 Eukystol (TN) Halojust AB00052008_23 MLS001146904 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone Haloperidol (JP17/USP/INN) AKOS000280660 NCGC00015500-05 Haloperidol [USAN:USP:INN:BAN:JAN] Aloperidon 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine NCGC00015500-13 Halopidol Biomol-NT_000035 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone NCGC00023875-04 HMS2095G12 BRN 0331267 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone NINDS_000654 Serenase SPBio_001236 SR-01000003076 Tox21_110162 Vesalium 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one NSC 615296 IDI1_000654 CAS-52-86-8 4763-EP2272537A2 Oprea1_509923 KBio2_003909 cMAP_000037 4763-EP2295412A1 Picroside-III KBioSS_001341 Dozic (TN) 4763-EP2311801A1 Probes1_000255 LNEPOXFFQSENCJ-UHFFFAOYSA- Einalon S MCULE-3693790133 FT-0697842 Haloperido AC-19691 N1910 Haldol Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard Aloperidin (TN) NCGC00015500-08 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material API0002885 177716-59-5 NCGC00015500-16 Halosten (TN) BPBio1_000144 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone NCGC00023875-07 HMS3370H11 BSPBio_000130 SC 170973 Sernas Spectrum2_001268 SR-01000003076-8 Tox21_500583 W0039 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	76.0 nM	PMID2895008	BindingDB
Ratio	0.78 -	PMID11784139	ChEMBL

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