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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	N,N-di-n-propyldopamine
Molecular formula	C14H23NO2
IUPAC name	4-[2-(dipropylamino)ethyl]benzene-1,2-diol
Molecular weight	237.343
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.8
Synonyms	Biomol-NT_000072 CTK5C3605 NCGC00015296-01 SCHEMBL467093 4-(2-Dipropylamino-ethyl)-benzene-1,2-diol (N,N-dipropyldopamine) 66185-61-3 C14H23NO2 DTXSID50216371 NCGC00015296-04 AKOS030547944 LS-176503 PDSP1_000638 4-(2-(Dipropylamino)ethyl)-1,2-benzenediol BPBio1_001388 Dipropyldopamine NCGC00015296-02 ZINC2539818 4-[2-(dipropylamino)ethyl]benzene-1,2-diol AC1L1F6N CCG-204557 Lopac-D-031 NCGC00162162-01 BDBM50019396 CHEMBL15564 PDSP2_000633 4-(2-Dipropylamino-ethyl)-benzene-1,2-diol BRD-K82577285-001-01-7 DPDA NCGC00015296-03 AC1Q7AD0 CHEBI:93446 Lopac0_000465 NCGC00162162-02 [ Show all ]
Inchi Key	LMYSNFBROWBKMB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H23NO2/c1-3-8-15(9-4-2)10-7-12-5-6-13(16)14(17)11-12/h5-6,11,16-17H,3-4,7-10H2,1-2H3
PubChem CID	3106
ChEMBL	CHEMBL15564
IUPHAR	N/A
BindingDB	50019396
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	12500.0 nM	PMID2955118	BindingDB,ChEMBL
Ki	4677.0 nM	N/A	BindingDB
Ki	4677.35 nM	Bioorg. Med. Chem. Lett., (1995) 5:20:2371	ChEMBL

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