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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd1
Synonym	D1 receptor D1A DADR Dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	Q61616
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3071
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SKF-75670
Molecular formula	C17H19NO2
IUPAC name	3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
Molecular weight	269.344
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.0
Synonyms	3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol CCG-205164 NCGC00015942-03 D0V4FZ SCHEMBL11712694 BDBM81986 Lopac0_001087 3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride NCGC00162337-01 GTPL936 Skf 75670 2,3,4,5-Tetrahydro-3-methyl-1-phenyl-1H-3-benzazepine-7,8-diol CAS_173870 NCGC00015942-02 3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol CHEMBL1193571 NSC_173870 AC1L5AM7 L000564 [ Show all ]
Inchi Key	LIHCKGZEDBNUJG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19NO2/c1-18-8-7-13-9-16(19)17(20)10-14(13)15(11-18)12-5-3-2-4-6-12/h2-6,9-10,15,19-20H,7-8,11H2,1H3
PubChem CID	173871
ChEMBL	CHEMBL1193571
IUPHAR	936
BindingDB	81986
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.9 nM	PMID2895008	BindingDB

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