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Name | Thyrotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Trhr |
Synonym | Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor |
Disease | N/A for non-human GPCRs |
Length | 412 |
Amino acid sequence | MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI |
UniProt | Q01717 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4553 |
IUPHAR | 363 |
DrugBank | N/A |
Name | CHEMBL2371825 |
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Molecular formula | C21H29N6O5+ |
IUPAC name | 1-[(4S)-5-[(2S)-2-carbamoylpyrrolidin-1-yl]-5-oxo-4-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentyl]pyridin-1-ium-3-carboxamide |
Molecular weight | 445.5 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 4 |
XlogP | -2.3 |
Synonyms | N/A |
Inchi Key | LHYYFEMGRONARO-JYJNAYRXSA-O |
Inchi ID | InChI=1S/C21H28N6O5/c22-18(29)13-4-1-9-26(12-13)10-2-5-15(25-20(31)14-7-8-17(28)24-14)21(32)27-11-3-6-16(27)19(23)30/h1,4,9,12,14-16H,2-3,5-8,10-11H2,(H5-,22,23,24,25,28,29,30,31)/p+1/t14-,15-,16-/m0/s1 |
PubChem CID | 73351706 |
ChEMBL | CHEMBL2371825 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID15537357 | ChEMBL |
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