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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL384626
Molecular formulaC29H34N4O3
IUPAC name4-(3,4-dimethylphenoxy)-3-[[methyl(phenyl)carbamoyl]amino]-N-(2-pyrrolidin-1-ylethyl)benzamide
Molecular weight486.616
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.7
SynonymsBDBM50192537
SCHEMBL5155131
3-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)phenyl)-1-methyl-1-phenylurea
Inchi KeyLDTSYWQDZCFPED-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H34N4O3/c1-21-11-13-25(19-22(21)2)36-27-14-12-23(28(34)30-15-18-33-16-7-8-17-33)20-26(27)31-29(35)32(3)24-9-5-4-6-10-24/h4-6,9-14,19-20H,7-8,15-18H2,1-3H3,(H,30,34)(H,31,35)
PubChem CID11663109
ChEMBLCHEMBL384626
IUPHARN/A
BindingDB50192537
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID16887348ChEMBL

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