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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Rattus norvegicus (Rat)
Gene	Grm7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	915
Amino acid sequence	MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	P35400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879
IUPHAR	295
DrugBank	N/A

Ligand

Name	CHEMBL595840
Molecular formula	C19H14N2O2
IUPAC name	5-methyl-3,6-diphenyl-[1,2]oxazolo[4,5-c]pyridin-4-one
Molecular weight	302.333
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.3
Synonyms	5-methyl-3,6-diphenyl-isoxazolo[4,5-c]pyridin-4(5H)-one AC1Q3XQS D06ICW MDI-P 3,6-DIPHENYL-5-METHYLISOXAZOLO(4,5-C)PYRIDIN-4(5H)-ONE 5-methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one BDBM50305859 GTPL6218 SMR001229079 5-methyl-3,6-diphenyl-4H,5H-pyrido[3,4-d][1,2]oxazol-4-one cid_4250909 LCNDUGHNYMJGIW-UHFFFAOYSA-N 5-methyl-3,6-diphenyl-isoxazolo[4,5-c]pyridine-4(5H)-one AC1Q3XQT DTXSID10401226 MLS002153017 3,6-Diphenyl-5-methylisoxazolo[4,5-c]pyridin-4(5H)-one HMS2206G07 ZINC394853 5-methyl-3,6-diphenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one AC1N5X7T CTK5B2529 MCULE-8467817198 5-methyl-3,6-diphenyl-[1,2]oxazolo[4,5-c]pyridin-4-one AKOS024323421 FT-0714059 SCHEMBL3663640 5-methyl-3,6-di(phenyl)-[1,2]oxazolo[4,5-c]pyridin-4-one 60986-80-3 HMS3358C19 [ Show all ]
Inchi Key	LCNDUGHNYMJGIW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14N2O2/c1-21-15(13-8-4-2-5-9-13)12-16-17(19(21)22)18(20-23-16)14-10-6-3-7-11-14/h2-12H,1H3
PubChem CID	4250909
ChEMBL	CHEMBL595840
IUPHAR	6218
BindingDB	50305859
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	20.0 nM	PMID20005101	BindingDB,ChEMBL
IC50	26.0 nM	PMID17609420	IUPHAR

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