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GPCR

NameMetabotropic glutamate receptor 7
SpeciesHomo sapiens (Human)
GeneGRM7
SynonymGLUR7
glutamate receptor
GPRC1G
mGlu7 receptor
mGlu7a receptor
[ Show all ]
DiseaseN/A
Length915
Amino acid sequenceMVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProtQ14831
Protein Data Bank5c5c, 3mq4
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5c5c.
BioLiPBL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3777
IUPHAR295
DrugBankBE0000834

Ligand

NameCHEMBL442076
Molecular formulaC5H10NO5P
IUPAC name2-amino-2-[(1R,2S)-2-phosphonocyclopropyl]acetic acid
Molecular weight195.111
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP-4.7
Synonyms(2S,1''R,2''S)-2-(2''-phosphonocyclopropyl)glycine
BDBM50207814
D0P2VP
(2S,1'R,2'S)-2-(2'-phosphonocyclopropyl)glycine
Inchi KeyKZOMBNQLBSHMFV-LPGMDIISSA-N
Inchi IDInChI=1S/C5H10NO5P/c6-4(5(7)8)2-1-3(2)12(9,10)11/h2-4H,1,6H2,(H,7,8)(H2,9,10,11)/t2-,3-,4?/m0/s1
PubChem CID11708219
ChEMBLCHEMBL442076
IUPHARN/A
BindingDB50207814
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50700000.0 nMPMID17350267BindingDB,ChEMBL

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