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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392156
Molecular formula	C18H10F3NO5
IUPAC name	4-oxo-8-[[4-(trifluoromethyl)benzoyl]amino]chromene-2-carboxylic acid
Molecular weight	377.275
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	3.0
Synonyms	BDBM50436030
Inchi Key	KWQQLPCMVMIVLX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H10F3NO5/c19-18(20,21)10-6-4-9(5-7-10)16(24)22-12-3-1-2-11-13(23)8-14(17(25)26)27-15(11)12/h1-8H,(H,22,24)(H,25,26)
PubChem CID	71735035
ChEMBL	CHEMBL2392156
IUPHAR	N/A
BindingDB	50436030
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	15500.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	81.0 %	PMID23713606	ChEMBL
Ki	10300.0 nM	PMID23888932	BindingDB,ChEMBL

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