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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL1933356
Molecular formula	C23H24ClN3O4
IUPAC name	3-[[4-[1-[1-(3-chlorophenyl)pyrazol-4-yl]oxybutyl]benzoyl]amino]propanoic acid
Molecular weight	441.912
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.0
Synonyms	BDBM50360590
Inchi Key	AZAURIGUHAXSLI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24ClN3O4/c1-2-4-21(16-7-9-17(10-8-16)23(30)25-12-11-22(28)29)31-20-14-26-27(15-20)19-6-3-5-18(24)13-19/h3,5-10,13-15,21H,2,4,11-12H2,1H3,(H,25,30)(H,28,29)
PubChem CID	57391684
ChEMBL	CHEMBL1933356
IUPHAR	N/A
BindingDB	50360590
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kb	16900.0 nM	PMID22119466	ChEMBL
Ki	1090.0 nM	PMID22119466	BindingDB,ChEMBL

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