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GPCR

NameD(2) dopamine receptor
SpeciesChlorocebus aethiops (Green monkey)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRSHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKNHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP52702
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5456
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1794814
Molecular formulaC26H26FN3O8
IUPAC name(Z)-but-2-enedioic acid;N-[[2-(3-fluorophenyl)-1H-imidazol-5-yl]methyl]-N-methyl-1-phenylmethanamine
Molecular weight527.505
Hydrogen bond acceptor11
Hydrogen bond donor5
XlogPNone
SynonymsN/A
Inchi KeyKRZYVHFZRHATQV-SPIKMXEPSA-N
Inchi IDInChI=1S/C18H18FN3.2C4H4O4/c1-22(12-14-6-3-2-4-7-14)13-17-11-20-18(21-17)15-8-5-9-16(19)10-15;2*5-3(6)1-2-4(7)8/h2-11H,12-13H2,1H3,(H,20,21);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
PubChem CID56672907
ChEMBLCHEMBL1794814
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki460.0 nMPMID7783157ChEMBL

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